The new IANAS Amazon Initiative aims to enhance the visibility of Science as a fundamental tool for building sustainable development solutions for the Amazon. This biome requires collective efforts from all nations around the world, including the countries of the Americas and especially those of the Amazon. IANAS is uniquely positioned to represent and integrate the recommendations from national science academies of the region with other leading scientific organizations such as the Science Panel for the Amazon (SPA), The World Academy of Science (TWAS) Latin America and Caribbean Regional Partner. The Amazon Initiative will bring new voices and insights to the regional and global arena, adding to what other government and nongovernmental organizations are already doing in the Amazon. The collective engagement of Academies through IANAS will provide independent, evidence-based advice for policy makers at the local, regional, and global levels on the Amazon and its impact on global environmental changes that affect food and water security, health, biodiversity, and natural disasters, among other pressing concerns. The Amazon Initiative was launched with a virtual meeting on 26 June 2023, and will continue with an in-person meeting in Manaus, Brazil from 1-3 August 2023. Stay tuned for updates on the IANAS Statement for the Amazon and future activities of the Amazon Initiative.